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  • Zacin® (capsaicin cream 0.025%)


    (capsaicin cream 0.025%)

Prescribing Zacin®

Zacin® (capsaicin cream 0.025%)

Therapeutic indications

Zacin® (capsaicin cream 0.025%) is for the symptomatic relief of pain associated with osteoarthritis.1

About Zacin®

Zacin® (capsaicin cream 0.025%) is for topical application.1

Capsaicin renders skin insensitive to pain by depleting and preventing re-accumulation of Substance P in peripheral sensory neurons.1

For the full list of excipients, see Section 6.1 of the Summary of Product Characteristics.

Facts about Zacin®

In a double-blind, randomised study in 70 patients with knee osteoarthritis, Zacin® resulted in a significantly greater reduction in visual analogue scale pain scores compared to placebo (p=0.026) at 2 weeks. Also, the number of patients reporting severe/very severe pain reduced from 52% at baseline to 22% at week two (p<0.01).2
Significant reduction in pain at two weeks vs placebo2

Interaction with other medicinal products and other forms of interaction.

No interaction studies have been performed, see Section 4.5 of the Summary of Product Characteristics.1

Clinical studies have shown no drug interactions3 with Zacin® (particularly beneficial in patients on multiple drug regimens e.g. the elderly).2

Marketing Authorisation

Cephalon UK Limited
Ridings Point, Whistler Drive
Castleford, West Yorkshire
WF10 5HX
United Kingdom

Marketing Authorisation Number(s)

  • PL 16260/0028

Resources for Zacin®

You can ask a question, request to see a representative from Teva, or report a side effect.

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Medicine supporting documentation for Zacin®

1 Zacin® (capsaicin cream 0.025%) Summary of Product Characteristics.

2 Deal CL, Schnitzer TJ, Lipstein E, et al. Treatment of arthritis with topical capsaicin: a double-blind trial. Clin Ther 1991; 13: 383-393.

3 Schnitzer TJ, Morton C, Coker S, et al. Topical capsaicin for osteoarthritis pain: achieving a maintenance regimen. Semin Arthiritis Rheu 1994; 23 (Suppl. 3): 34-40.

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